The DetectX® Dehydroepiandrosterone sulfate (DHEA-S) Immunoassay Kit uses a specifically generated antibody to measure DHEA-S in serum, plasma, urine, and saliva samples. The kit will also measure DHEA-S present in fecal extracts and tissue culture media samples. Standards or diluted samples are pipetted into a clear microtiter plate coated with an antibody to capture sheep antibodies. A DHEA-S-peroxidase conjugate is added to the standards and samples in the wells. The binding reaction is initiated by the addition of a polyclonal antibody to DHEA-S to each well. After a 2 hour incubation the plate is washed and substrate is added. The substrate reacts with the bound DHEA-S-peroxidase conjugate. The intensity of the generated color is detected in a microtiter plate reader at 450nm.
DHEA-S is primarily produced by the adrenal glands and it is useful as a marker for adrenal function. Adrenal tumors, cancers, and hyperplasia can lead to the overproduction of DHEA-S. High DHEA-S levels can lead to amenorrhea and visible symptoms of virilization. These changes vary in severity and may include: a deeper voice, hirsutism, male pattern baldness, muscularity, acne and enlargement of the Adam’s apple. Women with polycystic ovary syndrome tend to have elevated levels of DHEA-S. Excess levels of DHEA-S in children can cause precocious puberty in boys; and ambiguous external genitalia, excess body hair, and abnormal menstrual periods in girls.
Arbor Assays公司成立于2007年，位于密歇根州的安娜堡，公司的三位主创始人均为有多年科研经验的生命和临床科学家。其宗旨是为临床使用的重要生物分子建立高质量的检测和免疫测试产品。在生物领域建立健全的免疫检测和酶活性试剂盒以定量生物分子。
Arbor Assays公司的主要产品包括：
DetectX® Kits
Inhibitors & Activators
AbX® Antibodies & Affinity Resins
Detection Systems
Components & Ancillary Reagents
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